Contents

MLCK Gene

🧬 Gene Info

Gene Symbol	MLCK
Full Name	Myosin light chain kinase
Chromosome	3p21.31
Protein Type	Kinase
Target Class	Kinase
Function	MLCK inhibitors block the phosphorylation of myosin light chains, thereby reducing cytoskeletal contraction and stabilizing tight junctions at the blood-brain barrier and endothelial surfaces. This...
Mechanism of Action	MLCK inhibitors block the phosphorylation of myosin light chains, thereby reducing cytoskeletal contraction and stabilizing tight junctions at the blood-brain barrier and endothelial surfaces. This mechanism reduces vascular permeability and preserves barrier integrity in conditions characterized by excessive leakage or cytoskeletal dysfunction.
Primary Expression	Brain (cerebellum), Smooth muscle, Heart
Druggability	Low (0.40)
Clinical Stage	Phase II
Molecular Weight	220 kDa
Gene Type	Protein coding
Pathways	Nf-Κb
UniProt ID	Q9Y463
NCBI Gene ID	3371
Ensembl ID	ENSG00000139792
OMIM	600922
GeneCards	MLCK
Human Protein Atlas	MLCK
Associated Diseases	ALS, neurodegeneration, stroke
Known Drugs/Compounds	Lifibrate
Interactions	CLDN1, OCLN, ZO1, TNF, PPAR, p-MLC
SciDEX Target	View Target Profile (4 clinical trials)
KG Connections	294 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph