| Gene Symbol | CASP1 |
| Aliases | Caspase-1, ICE, IL-1β converting enzyme |
| Chromosome | 11q22.3 |
| Protein Type | Protease |
| Target Class | Protease |
| Function | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Mechanism of Action | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase II |
| Molecular Weight | 45 kDa |
| Amino Acids | 404 aa |
| Exons | 11 |
| Pathways | NF-κB |
| UniProt ID | P29465 |
| NCBI Gene ID | 842 |
| GeneCards | CASP1 |
| Human Protein Atlas | CASP1 |
| Associated Diseases | ALS, ALZHEIMER, Aging, Atherosclerosis, Cancer |
| Known Drugs/Compounds | Pterostilbene, rapamycin, KAEMPFEROL |
| Interactions | NLRP3, IL1B, PYCARD, SNCA, ASC, SQSTM1 |
| SciDEX Target | View Target Profile (3 clinical trials) |
| KG Connections | 851 knowledge graph edges |
| Databases | GeneCardsHPASTRING |