gene 1,524 words KG: NEUROG1 2026-03-28
kind:genesection:genesstate:published
Contents

NEUROG1 (Neurogenin-1)

🧬 Gene Info
Gene SymbolNEUROG1
Full NameNeurogenin-1
Chromosome9q34.3
Protein TypeTranscription Factor
Functionis a Class A basic helix-loop-helix (bHLH) transcription factor that functions as a potent proneural gene essential for the development of specific neuronal populations.
Amino Acids237 aa
Exons2
PathwaysEpigenetic, epigenetic regulation, oxidative stress response
UniProt IDQ96TT8
NCBI Gene ID4744
Ensembl IDENSG00000181965
OMIM605526
GeneCardsNEUROG1
Human Protein AtlasNEUROG1
Encoded ProteinNeurogenin-1
Associated Diseasesneurodegeneration
InteractionsTP53, APC, PMS2, ARID1A, Rb, KRAS
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
MLH1 Gene
gene · KG edge: associated_with
cdkn2a
gene · KG edge: associated_with
CACNA1G Gene
gene · KG edge: associated_with
ARID1A
gene · KG edge: activates

Knowledge Graph (12 edges)

NEUROG1 activates TP53
NEUROG1 activates APC
NEUROG1 biomarker_for MLH1
NEUROG1 activates PMS2
NEUROG1 biomarker_for CACNA1G
NEUROG1 associated_with CDKN2A
NEUROG1 associated_with CACNA1G
NEUROG1 associated_with MLH1
NEUROG1 encodes TP53
NEUROG1 methylates MLH1