| Gene Symbol | APC |
| Chromosome | 5q22.2 |
| Protein Type | Gene |
| Function | is a tumor suppressor gene originally identified for its role in colorectal cancer, but increasingly recognized for its critical functions in the central nervous system. |
| Amino Acids | 843 aa |
| Pathways | Akt, Autophagy, Epigenetic, Mapk, Mtor |
| UniProt ID | P25054 |
| NCBI Gene ID | 324 |
| Ensembl ID | ENSG00000134982 |
| GeneCards | APC |
| Human Protein Atlas | APC |
| Oligomerization domain (N-terminus) | Allows APC to form homodimers and heterodimers, essential for its scaffold function. |
| Armadillo repeats | Mediate interactions with beta-catenin, B-catenin, and other proteins containing armadillo repeat domains. |
| 15-amino acid repeats | Bind to beta-catenin with varying affinities. The SAMP repeats mediate beta-catenin degradation. |
| Basic domain | Binds to microtubules and regulates cytoskeletal dynamics. |
| Associated Diseases | Aging, Als, Cancer, Carcinoma, Colorectal Cancer, Tumor |
| Known Drugs/Compounds | rapamycin |
| Interactions | ADNP, AKT, AKT1, AKT1S1, AND, APOPTOSIS |
| KG Connections | 599 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!