gene 1,972 words KG: NLRC5 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammationstate:published
Contents

NLRC5 — NLR Family CARD Domain Containing 5

🧬 Gene Info
Gene SymbolNLRC5
Full NameNLR Family CARD Domain Containing 5
Chromosome16q13
Protein FamilyNLR (NOD-like receptor) family
Functionregulating MHC class I expression and innate immunity
Primary ExpressionUbiquitous, high in immune cells
Molecular Weight220 kDa
Amino Acids2000 aa
PathwaysNF-κB
UniProt ID[Q86TI2](https://www.uniprot.org/uniprot/Q86TI2)
Ensembl IDENSG00000148488
OMIM613851
GeneCardsNLRC5
Human Protein AtlasNLRC5
Associated DiseasesInfectious Disease, Inflammatory Disease
Known Drugs/CompoundsHeme, PAMP
InteractionsCD8, IRF1, CIITA, NPM1, NLRP12, Panoptosome
KG Connections85 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: regulates
IRF1 Gene - Interferon Regulatory Factor 1
gene · KG edge: activates
Class II Major Histocompatibility Complex Transactivato
gene · KG edge: activates
CDK5 Gene
gene · KG edge: inhibits
CD8 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NLRC5 activates CD8
NLRC5 activates IRF1
NLRC5 activates CIITA
NLRC5 activates NPM1
NLRC5 interacts_with NLRP12
NLRC5 promotes PANoptosis
NLRC5 regulates inflammatory cell death
NLRC5 activates innate immune response
NLRC5 activates Smad2/3
NLRC5 interacts_with Panoptosome