gene 787 words KG: APLP1 2026-03-27
kind:genesection:genestopic:alzheimersstate:published
Contents

APLP1 Gene

🧬 Gene Info
Gene SymbolAPLP1
Full NameAmyloid Beta Precursor-Like Protein 1
Chromosome19q13.3
Functionis a type I transmembrane glycoprotein expressed predominantly in the nervous system, where it participates in diverse cellular processes including synapse development, plasticity, and network exci...
Primary Expressionthe central nervous system with particularly high levels in the hippocampus (especially CA1 pyramidal neurons and dentate gyrus granule cells), cerebr
Amino Acids770 aa
UniProt ID[Q15804](https://www.uniprot.org/uniprot/Q15804)
Ensembl IDENSG00000105248
GeneCardsAPLP1
Human Protein AtlasAPLP1
Associated DiseasesAls
Known Drugs/Compoundscurcumin, resveratrol
InteractionsAKT, ADAM10, SOD1, APOE, CLDN5, MMP9
KG Connections101 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: contributes_to
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: protects_against
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with

Knowledge Graph (12 edges)

APLP1 activates AKT
APLP1 protects_against APP
APLP1 activates ADAM10
APLP1 regulates NPAS4
APLP1 regulates APP
APLP1 interacts_with LAG3
APLP1 involved_in Alpha-Synuclein Transmission
APLP1 interacts_with SOD1
APLP1 interacts_with APOE
APLP1 interacts_with CLDN5