gene 2,790 words KG: PDIA3 2026-03-28
kind:genesection:genesstate:published
Contents

PDIA3 - Protein Disulfide Isomerase Family A Member 3

🧬 Gene Info
Gene SymbolPDIA3
Full NameProtein Disulfide Isomerase Family A Member 3
AliasesPage for PDIA3
Chromosome15q15.3
Functionis a multifunctional endoplasmic reticulum (ER)-resident protein that plays critical roles in protein folding, redox homeostasis, calcium signaling, and cellular stress responses.
Molecular Weight57 kDa
Amino Acids505 aa
PathwaysAutophagy, Circadian Rhythm, Mtor, Nf-Κb
UniProt ID[P27773](https://www.uniprot.org/uniprot/P27773)
Ensembl IDENSG00000167077
GeneCardsPDIA3
Human Protein AtlasPDIA3
Associated Diseasesneurodegeneration
InteractionsDNA, TGF-β, ERP57, MYC, XPA, CLOCK
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
MYC Gene
gene · KG edge: activates
MTOR Gene
gene · KG edge: regulates
ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Me
gene · KG edge: activates

Knowledge Graph (12 edges)

PDIA3 regulates BMAL1
PDIA3 regulates AHR
PDIA3 regulates MTOR
PDIA3 expressed_in Als
PDIA3 activates Unfolded Protein Response
PDIA3 expressed_in Autophagy
PDIA3 regulates CIRCADIAN RHYTHM
PDIA3 activates Senescence
PDIA3 regulates Aging
PDIA3 activates Als