gene 1,654 words KG: XPA 2026-03-24
kind:genesection:genesstate:published
Contents

XPA Gene

🧬 Gene Info
Gene SymbolXPA
Full NameXPA DNA Repair Endonuclease
Chromosome9q34.3
FunctionXPA encodes a zinc-finger protein essential for nucleotide excision repair (NER).
Molecular Weight32 kDa
Amino Acids297 aa
PathwaysAutophagy, Circadian Rhythm, Mtor, Nf-Κb
UniProt IDP18077
NCBI Gene ID7508
Ensembl IDENSG00000136936
OMIM278700
GeneCardsXPA
Human Protein AtlasXPA
Encoded ProteinDNA repair protein XPA
Associated Diseasesneurodegeneration
InteractionsCLOCK, PDIA3, DNA, MYC, AND, C-MYC
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
PDIA3 - Protein Disulfide Isomerase Family A Member 3
gene · KG edge: activates
MYC Gene
gene · KG edge: activates
MTOR Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

XPA activates CLOCK
XPA activates PDIA3
XPA regulates BMAL1
XPA regulates AHR
XPA regulates MTOR
XPA regulates AUTOPHAGY
XPA regulates CIRCADIAN RHYTHM
XPA activates Senescence
XPA regulates Aging
XPA activates Als