gene 3,072 words KG: ERP57 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:als
Contents

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

🧬 Gene Info
Gene SymbolERP57
AliasesProtein Disulfide Isomerase Family A Member 3
Chromosome15q15.3
Protein FamilyPDI family
Protein TypeChaperone
Functionis a critical endoplasmic reticulum (ER) chaperone protein that plays essential roles in protein folding, disulfide bond formation, and ER stress responses.
Molecular Weight57 kDa
Amino Acids505 aa
Exons13
PathwaysMapk, Mtor, Pi3K/Akt
UniProt ID[P30101](https://www.uniprot.org/uniprot/P30101)
Ensembl IDENSG00000123131
OMIM602046
GeneCardsERP57
Human Protein AtlasERP57
Associated Diseasesneurodegeneration
InteractionsPDIA3, CANCER, AUTOPHAGY, ROS, APOPTOSIS, INFLAMMATION
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (13)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
SRC Gene
gene · KG edge: regulates
PDIA3 - Protein Disulfide Isomerase Family A Member 3
gene · KG edge: activates
MYC Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

ERP57 activates PDIA3
ERP57 regulates MYC
ERP57 regulates AKT
ERP57 regulates SRC
ERP57 regulates MTOR
ERP57 expressed_in Als
ERP57 activates Unfolded Protein Response
ERP57 expressed_in Autophagy
ERP57 activates CANCER
ERP57 activates Tumor