gene 640 words KG: PDIA6 2026-03-29
kind:genesection:genesstate:published
Contents

PDIA6 - Protein Disulfide Isomerase Family A Member 6

🧬 Gene Info
Gene SymbolPDIA6
Full NameProtein Disulfide Isomerase Family A Member 6
AliasesERP29/P5
Chromosome2p25.1
Protein TypeIsomerase
FunctionPDIA6 functions as a chaperone and assists in protein folding in the endoplasmic reticulum.
Primary Expressionmost tissues with high expression in brain, lung, and pancreas
Molecular Weight48 kDa
PathwaysApoptosis, apoptosis, apoptosis pathway
UniProt ID[Q15020](https://www.uniprot.org/uniprot/Q15020)
Ensembl IDENSG00000143870
GeneCardsPDIA6
Human Protein AtlasPDIA6
PDI (PDIA1)Canonical protein disulfide isomerase and PDIA6 family prototype
GRP78/BiPER chaperone and PDIA6 interaction partner
Associated Diseasesneurodegeneration
InteractionsSLC16A1, APOPTOSIS, AND, Insulin, IL1A
KG Connections28 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
SLC16A1 — Solute Carrier Family 16 Member 1 (Monocarbox
gene · KG edge: activates
PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1
gene · KG edge: protects_against
IL1A — Interleukin 1 Alpha
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PDIA6 activates SLC16A1
PDIA6 associated_with SLC16A1
PDIA6 biomarker_for SLC16A1
PDIA6 interacts_with Ms
PDIA6 interacts_with Carcinoma
PDIA6 interacts_with Unfolded Protein Response
PDIA6 expressed_in Diabetes
PDIA6 activates Apoptosis
PDIA6 biomarker_for GENES
PDIA6 activates APOPTOSIS