gene 559 words KG: XBP1
Contents

XBP1 — X-Box Binding Protein 1

🧬 Gene Info
Gene SymbolXBP1
Full NameX-Box Binding Protein 1
AliasesPage for XBP1
Chromosome22q12.1
Protein TypeTranscription Factor
FunctionER Expansion and Biogenesis: Increases ER membrane synthesis and volume
Primary ExpressionBrain, Liver, Pancreas, Immune cells
Molecular Weight29 kDa
Amino Acids261 aa
PathwaysAutophagy, Er Stress, Glycolysis, Mitophagy, Unfolded Protein Response
UniProt IDP17861
NCBI Gene ID7499
Ensembl IDENSG00000143419
GeneCardsXBP1
Human Protein AtlasXBP1
Associated DiseasesTumor
InteractionsDDIT3, HSPA5, ATF3, TOMM20, PTEN, USP30
KG Connections261 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Circadian Clock-Autophagy Synchronization
Score: 0.55
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: activates
DDIT3 Gene
gene · KG edge: activates
CXCL2 — C-X-C Motif Chemokine Ligand 2
gene · KG edge: activates
CXCL1
gene · KG edge: activates
COX4I1
gene · KG edge: activates

Knowledge Graph (12 edges)

XBP1 therapeutic_target CXCL1
XBP1 activates DDIT3
XBP1 therapeutic_target CLDN5
XBP1 activates HSPA5
XBP1 therapeutic_target OCLN
XBP1 therapeutic_target IL23A
XBP1 activates ATF3
XBP1 activates TOMM20
XBP1 activates PTEN
XBP1 activates USP30