gene 898 words KG: ERN1 2026-03-24
kind:genesection:genesstate:published
Contents

ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1

🧬 Gene Info
Gene SymbolERN1
Full NameEndoplasmic Reticulum To Nucleus Signaling 1
Chromosome6p24.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids1210 aa
Exons54
PathwaysAkt, Apoptosis, Wnt
GeneCardsERN1
Human Protein AtlasERN1
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsPARKIN, FMR1, SNCA, FAM134B, LC3, EPAS1
KG Connections986 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Purinergic Signaling Polarization Control
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.52
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

ERN1 activates FAM134B
ERN1 activates FIP200
ERN1 activates FMR1
ERN1 activates FUNDC1
ERN1 activates G3BP1
ERN1 activates GBA
ERN1 activates HIF1A
ERN1 activates JNK
ERN1 activates LC3
ERN1 activates LGALS3