gene

IL1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Gene page for IL1A encoding interleukin-1 alpha, a key pro-inflammatory cytokine in neurodegeneration

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🧬 Gene Info

Gene Symbol	IL1A
Full Name	Interleukin 1 Alpha
Chromosome	2q14.1
Function	Unlike IL1B which is secreted as a mature protein, IL1A is active in both its pro-form and mature form.
Molecular Weight	31 kDa
Pathways	NF-κB, MAPK
GeneCards	IL1A
Human Protein Atlas	IL1A
Associated Diseases	A1_astrocytes, Als, Alzheimer, Inflammation, normal immune responses
Interactions	ALZHEIMER, App, BACE1, BDNF, CANCER, CD14
SciDEX Hypotheses	Sequential IL-1α and Complement Receptor Antagonis
KG Connections	197 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL1A — Interleukin 1 Alpha

gene · 1318 words

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Pathway Diagram

flowchart TD
    IL1A["IL1A"] -.->|"inhibits"| osteoblastogenesis["osteoblastogenesis"]
    IL1A["IL1A"] -->|"activates"| PIEZO1["PIEZO1"]
    IL1A["IL1A"] -->|"activates"| A1_ASTROCYTES["A1_ASTROCYTES"]
    MICROGLIA["MICROGLIA"] -->|"expressed in"| IL1A["IL1A"]
    IL1A["IL1A"] -->|"biomarker for"| Inflammation["Inflammation"]
    IL1A["IL1A"] -->|"biomarker for"| Als["Als"]
    IL1A["IL1A"] -->|"biomarker for"| Atherosclerosis["Atherosclerosis"]
    IL1A["IL1A"] -->|"biomarker for"| Ms["Ms"]
    IL1A["IL1A"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    IL1A["IL1A"] -.->|"inhibits"| Inflammation["Inflammation"]
    IL1A["IL1A"] -->|"activates"| Senescence["Senescence"]
    IL1A["IL1A"] -.->|"inhibits"| Cancer["Cancer"]
    style IL1A fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style osteoblastogenesis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style PIEZO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style A1_ASTROCYTES fill:#006494,stroke:#333,color:#e0e0e0
    style MICROGLIA fill:#006494,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (113)

Target	Relation	Type	Str
osteoblastogenesis	inhibits	pathway	0.90
PIEZO1	activates	gene	0.90
RGC death	causes	process	0.80
ASTROCYTE	induces_a1_phenotype	cell_type	0.80
A1 astrocyte	inhibits	cell_type	0.80
A1 astrocyte	causes	cell_type	0.80
A1_ASTROCYTES	activates	cell_type	0.72
microglial_activation	regulates	phenotype	0.70
A1_astrocytes	causes	phenotype	0.70
A1 astrocytes	activates	cell_type	0.70
normal immune responses	associated_with	phenotype	0.70
Inflammation	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	biomarker_for	disease	0.65
Als	activates	disease	0.65
Longevity	inhibits	disease	0.65
Tumor	activates	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Senescence	activates	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
IMMUNE_RESPONSE	activates	pathway	0.60
App	activates	protein	0.60
Nf-Κb	activates	pathway	0.60
Interferon Signaling	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
Fibroblast	activates	cell_type	0.60
INFLAMMATION	biomarker_for	gene	0.60
Bdnf	associated_with	protein	0.60
Il-1	activates	protein	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
TFCP2	associated_with	gene	0.60
CASP3	therapeutic_target	gene	0.60
MAOB	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
neuroinflammation	activates	disease	0.60
complement cascade	participates_in	pathway	0.60
Immune Response	interacts_with	pathway	0.60

Incoming (84)

Source	Relation	Type	Str
h-89500d80	targets	hypothesis	0.90
OCULAR HYPERTENSION	upregulates	process	0.80
MICROGLIA	secretes	cell_type	0.80
MICROGLIA	expressed_in	cell_type	0.72
BDNF	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
GSK3B	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
CANCER	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
INFLAMMATION-RELATED GENES	associated_with	gene	0.60
GENES	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	therapeutic_target	gene	0.60
TNF	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
TFCP2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
BCL2	therapeutic_target	gene	0.60
MAOB	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
BDNF	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
CCR9	biomarker_for	gene	0.60
MAPT	associated_with	gene	0.60
IDE	associated_with	gene	0.60
IL10	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
MTOR	activates	gene	0.60
IL6	inhibits	gene	0.60
CD14	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential IL-1α and Complement Receptor Antagonism for Brea	0.000	-	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 6 hypotheses Top: 0.682

Astrocyte Reactivity Subtypes in Neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Astrocyte Reactivity Subtypes in Neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

The debate mentioned gene expression profiling but did not specify which neural

closed · Rounds: 4 · Score: 0.93 · 2026-04-03

Related Research

Hypotheses and analyses mentioning IL1A in their description or question text

No additional research found