gene

IL1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

199Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Gene page for IL1A encoding interleukin-1 alpha, a key pro-inflammatory cytokine in neurodegeneration

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🧬 Gene Info

Gene Symbol	IL1A
Full Name	Interleukin 1 Alpha
Chromosome	2q14.1
Function	Unlike IL1B which is secreted as a mature protein, IL1A is active in both its pro-form and mature form.
Molecular Weight	31 kDa
Pathways	NF-κB, MAPK
GeneCards	IL1A
Human Protein Atlas	IL1A
Cell Type	Expression Pattern
Microglia	Constitutive low, dramatically upregulated by injury/pathology
Astrocytes	Moderate constitutive, stress-induced upregulation
Neurons	Low constitutive, pathological induction
Oligodendrocytes	Stress-responsive
Endothelial cells	Low, upregulated in inflammation
Drug	Mechanism
Associated Diseases	Als, Alzheimer, Inflammation
Interactions	XBP1, DNAJB9, ERN1, PDIA6, MTOR, SORL1
KG Connections	199 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    IL1A["IL1A"] -.->|"inhibits"| osteoblastogenesis["osteoblastogenesis"]
    IL1A["IL1A"] -->|"activates"| PIEZO1["PIEZO1"]
    IL1A["IL1A"] -->|"activates"| A1_ASTROCYTES["A1_ASTROCYTES"]
    MICROGLIA["MICROGLIA"] -->|"expressed in"| IL1A["IL1A"]
    IL1A["IL1A"] -->|"biomarker for"| Inflammation["Inflammation"]
    IL1A["IL1A"] -->|"biomarker for"| Als["Als"]
    IL1A["IL1A"] -->|"biomarker for"| Atherosclerosis["Atherosclerosis"]
    IL1A["IL1A"] -->|"biomarker for"| Ms["Ms"]
    IL1A["IL1A"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    IL1A["IL1A"] -.->|"inhibits"| Inflammation["Inflammation"]
    IL1A["IL1A"] -->|"activates"| Senescence["Senescence"]
    IL1A["IL1A"] -.->|"inhibits"| Cancer["Cancer"]
    style IL1A fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style osteoblastogenesis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style PIEZO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style A1_ASTROCYTES fill:#006494,stroke:#333,color:#e0e0e0
    style MICROGLIA fill:#006494,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
osteoblastogenesis	inhibits	pathway	0.90
PIEZO1	activates	gene	0.90
A1 astrocyte	causes	cell_type	0.80
RGC death	causes	biological_process	0.80
A1 astrocyte	inhibits	cell_type	0.80
ASTROCYTE	induces_a1_phenotype	cell_type	0.80
A1_ASTROCYTES	activates	cell_type	0.72
Inflammation	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Inflammation	inhibits	disease	0.65
Senescence	activates	disease	0.65
Cancer	inhibits	disease	0.65
Longevity	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
IMMUNE_RESPONSE	activates	pathway	0.60
LDLR	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
XBP1	interacts_with	gene	0.60
DNAJB9	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PDIA6	interacts_with	gene	0.60
CXCL2	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
MTOR	activates	gene	0.60
IL1RN	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
IL10	associated_with	gene	0.60
BCL2	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60

Incoming (87)

Source	Relation	Type	Str
h-89500d80	targets_gene	hypothesis	0.90
OCULAR HYPERTENSION	upregulates	biological_process	0.80
MICROGLIA	secretes	cell_type	0.80
MICROGLIA	expressed_in	cell_type	0.72
h-89500d80	targets	hypothesis	0.70
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
MTOR	activates	gene	0.60
IL6	inhibits	gene	0.60
PECAM1	interacts_with	gene	0.60
FOS	interacts_with	gene	0.60
FGF1	interacts_with	gene	0.60
FGF5	interacts_with	gene	0.60
LDLR	biomarker_for	gene	0.60
TNF	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
MAOA	therapeutic_target	gene	0.60
APP	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
GSK3B	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
MAOB	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
SORL1	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
IDE	associated_with	gene	0.60
IL10	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
IL1B	activates	gene	0.60
IRAK4	activates	gene	0.60
CSF2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL1A

Understanding Entity Pages

Summary

Wiki Pages (11)

IL1A — Interleukin 1 Alpha

Microglia

IL-1α Protein

IL-10 Protein

HTR3C Gene

IRAK4 Kinase Modulation Therapy for Neurodegeneration

FGF1 Gene

IRAK4 Protein

Fibroblast Growth Factor 5

Proteins