gene 1,318 words KG: IL1A
Contents

IL1A — Interleukin 1 Alpha

🧬 Gene Info
Gene SymbolIL1A
Full NameInterleukin 1 Alpha
Chromosome2q14.1
FunctionUnlike IL1B which is secreted as a mature protein, IL1A is active in both its pro-form and mature form.
Molecular Weight31 kDa
PathwaysNF-κB, MAPK
GeneCardsIL1A
Human Protein AtlasIL1A
Associated DiseasesA1_astrocytes, Als, Alzheimer, Inflammation, normal immune responses
InteractionsALZHEIMER, App, BACE1, BDNF, CANCER, CD14
SciDEX HypothesesSequential IL-1α and Complement Receptor Antagonis
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (5)

Which cell types show the most significant expression change
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

BACE1 (Redirect)
redirect · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
BAX Gene
gene · KG edge: therapeutic_target
BCL2 Gene
gene · KG edge: therapeutic_target
BDNF Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL1A activates A1_ASTROCYTES
IL1A activates IMMUNE_RESPONSE
NR4A2 biomarker_for IL1A
CXCL2 biomarker_for IL1A
CSF2 biomarker_for IL1A
STAT3 biomarker_for IL1A
MMP9 biomarker_for IL1A
JAK1 biomarker_for IL1A
HTR3C biomarker_for IL1A
NTS biomarker_for IL1A

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