| Gene Symbol | IL1A |
| Full Name | Interleukin 1 Alpha |
| Chromosome | 2q14.1 |
| Function | Unlike IL1B which is secreted as a mature protein, IL1A is active in both its pro-form and mature form. |
| Molecular Weight | 31 kDa |
| Pathways | NF-κB, MAPK |
| GeneCards | IL1A |
| Human Protein Atlas | IL1A |
| Cell Type | Expression Pattern |
| Microglia | Constitutive low, dramatically upregulated by injury/pathology |
| Astrocytes | Moderate constitutive, stress-induced upregulation |
| Neurons | Low constitutive, pathological induction |
| Oligodendrocytes | Stress-responsive |
| Endothelial cells | Low, upregulated in inflammation |
| Drug | Mechanism |
| Associated Diseases | Als, Alzheimer, Inflammation |
| Interactions | XBP1, DNAJB9, ERN1, PDIA6, MTOR, SORL1 |
| KG Connections | 199 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |