| Gene Symbol | PLIN3 |
| Function | encodes a lipid droplet-associated protein that plays crucial roles in lipid metabolism, autophagy regulation, and lysosomal function. |
| Primary Expression | various tissues with specific patterns: |
| Molecular Weight | 47 kDa |
| Pathways | autophagy pathway, Phagocytosis, Mtor, Autophagy, complement cascade |
| Ensembl ID | ENSG00000138326 |
| GeneCards | PLIN3 |
| Human Protein Atlas | PLIN3 |
| Coats lipid droplet surface | Forms a monomolecular layer on the droplet surface |
| Regulates size | Controls lipid droplet growth and coalescence |
| Prevents lipolysis | Protects stored triglycerides from ATGL-mediated hydrolysis |
| Recruits proteins | Attracts lipases and other regulatory proteins |
| Lipid droplet recognition | PLIN3 marks droplets for selective autophagy |
| Autophagosome recruitment | Facilitates LC3 binding to lipid droplets |
| Lysosomal fusion | Coordinates droplet delivery to lysosomes |
| Associated Diseases | Neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | BECN1, GRK2, FOXO1, NR1H3, MAP3K5, SREBF2 |
| KG Connections | 208 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |