| Gene Symbol | STING1 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | DNA sensing: cGAS (cyclic GMP-AMP synthase) binds cytosolic dsDNA from any source — mitochondrial, nuclear, microbial, or retrotransposon-derived |
| Mechanism of Action | Small molecule agonists or antagonists of cGAS-STING pathway activation |
| Druggability | Low (0.40) |
| Clinical Stage | Phase II |
| Pathways | Akt, Autophagy, Immune Response, Wnt, innate_immune_response |
| UniProt ID | A0A494C1N5 |
| Ensembl ID | ENSG00000184584 |
| GeneCards | STING1 |
| Human Protein Atlas | STING1 |
| Associated Diseases | AD, ALI, ALS, AUTOIMMUNITY, Aging |
| Known Drugs/Compounds | cGAMP, rapamycin, PA treatment, palmitic acid, VS-X4, Palmitic Acid |
| Interactions | CGAS, DNASE2, TYPE_I_IFN, TAX1BP1, ATM, SNCAIP |
| SciDEX Target | View Target Profile (3 clinical trials) |
| SciDEX Hypotheses | Mitochondrial NAD+ Salvage Enhancement |
| KG Connections | 1291 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |