| Gene Symbol | KDM6B |
| Full Name | Lysine Demethylase 6B |
| Aliases | JMJD3 |
| Chromosome | 17p13.1 |
| Function | encodes a Jumonji C (JmjC) domain-containing histone demethylase that specifically removes di- and trimethyl marks from histone H3 lysine 27 (H3K27me2/3). |
| Pathways | NF-κB |
| UniProt ID | [O15054](https://www.uniprot.org/uniprot/O15054) |
| Ensembl ID | ENSG00000132510 |
| GeneCards | KDM6B |
| Human Protein Atlas | KDM6B |
| Neuronal differentiation | KDM6B removes H3K27me3 from neurogenic gene promoters during the transition from neural stem cells to postmitotic neurons, activating expression of NEUROD1, TBR1, and other neuronal identity genes |
| Macrophage polarization | KDM6B drives M1 (pro-inflammatory) macrophage/microglial polarization by activating inflammatory gene programs |
| Aging epigenome | KDM6B expression increases with aging, contributing to the progressive loss of H3K27me3 that characterizes the aging epigenome and potentially derepressing deleterious gene programs |
| Neuroinflammatory amplification | KDM6B removes H3K27me3 from pro-inflammatory gene promoters (TNF, IL1B, IL6, complement components), converting microglia to a chronic inflammatory state that damages neurons |
| [Tau](/proteins/tau) pathology | KDM6B activates kinase genes (CDK5, GSK3B) that hyperphosphorylate tau, promoting neurofibrillary tangle formation |
| Associated Diseases | NAFLD, NASH |
| Known Drugs/Compounds | rapamycin |
| Interactions | LC3, ATG7, RPTOR, PRKAA2, LAMP2, PLIN3 |
| KG Connections | 219 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |