gene 664 words KG: PPT1 2026-03-24
kind:genesection:genesstate:published
Contents

PPT1 Gene - Palmitoyl-Protein Thioesterase 1

🧬 Gene Info
Gene SymbolPPT1
AliasesPage for PPT1 Gene, Palmitoyl-Protein Thioesterase 1
Chromosome1p34.2
Protein FamilyPalmitoyl-protein thioesterase family
Protein TypeEnzyme
Function### Enzymatic Activity
Primary Expressionneurons and glia - Cellular Localization: Lysosomal lumen - Developmental Expression: High during fetal development and e
Molecular Weight34 kDa
Amino Acids306 aa
Exons9
UniProt IDP60617
NCBI Gene ID5538
Ensembl IDENSG00000131238
OMIM256730
GeneCardsPPT1
Human Protein AtlasPPT1
Associated Diseasesneurodegeneration
InteractionsTNF, SELF-DNA, ENDOSOMES, IFN, FERROPTOSIS, AUTOPHAGY
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (8)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: inhibits
TLR9 — Toll-Like Receptor 9
gene · KG edge: regulates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

PPT1 activates Macrophage
PPT1 activates Dendritic Cell
PPT1 inhibits Als
PPT1 activates Ferroptosis
PPT1 inhibits Cancer
PPT1 inhibits Autophagy
PPT1 therapeutic_target Ras
PPT1 data_in benchmark_ot_ad_answer_key:PPT1
PPT1 provides_data_for ds-83b31ef18d49
TLR9 regulates PPT1