gene 903 words KG: TLR9 2026-03-21
kind:genesection:genesstate:published
Contents

TLR9 — Toll-Like Receptor 9

🧬 Gene Info
Gene SymbolTLR9
Full NameToll-Like Receptor 9
Chromosome3p21.3
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmicroglia, astrocytes, and neurons, where it plays a critical role in innate immune responses to pathogen-a
PathwaysNF-κB, MAPK pathway
OMIM605203
GeneCardsTLR9
Human Protein AtlasTLR9
Protein ClassPattern Recognition Receptor
SpeciesHuman
Omim ID605203
Associated DiseasesALS, Carcinoma, Cirrhosis, Cystic Fibrosis, Fibrosis, Hepatitis
InteractionsMYD88, TLR4, TNF, TLR3, Rb, DNA
KG Connections216 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: protects_against
Packard Center for ALS Research
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
CLOCK Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

TLR9 regulates NET
TLR9 activates MYD88
TLR9 activates TLR4
TLR9 activates TNF
TLR9 activates TLR3
TLR9 associated_with TNF
TLR9 regulates NLRP3
TLR9 inhibits TNF
TLR9 regulates PPT1
TLR9 inhibits TLR4