gene 2,761 words KG: PRKCG 2026-03-28
kind:genesection:genesstate:published
Contents

PRKCG — Protein Kinase C Gamma

🧬 Gene Info
Gene SymbolPRKCG
Full NameProtein Kinase C Gamma
Chromosome19q13.42
Functionis a key mediator of the diacylglycerol (DAG) signaling pathway.
Primary ExpressionNeuron-specific
Molecular Weight89 kDa
Amino Acids697 aa
Exons17
UniProt ID[P05129](https://www.uniprot.org/uniprot/P05129)
Ensembl IDENSG00000156508
OMIM176980
GeneCardsPRKCG
Human Protein AtlasPRKCG
Associated DiseasesAtaxia, Neurodegeneration, Spinocerebellar Ataxia
InteractionsERK1
KG Connections34 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (5)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
PRKCA Gene
gene · KG edge: associated_with
Genes
index · KG edge: causes
Neurodegeneration
disease · KG edge: implicated_in
NeuRon Therapeutics
company · KG edge: associated_with

Knowledge Graph (12 edges)

PRKCG associated_with PKC
PRKCG expressed_in Purkinje Cell
PRKCG associated_with Purkinje
PRKCG associated_with Rb
PRKCG modulates Fragile X-associated tremor/ataxia syndrome
PRKCG contributes_to neurodegeneration
PRKCG targets therapeutic_target
PRKCG promotes disease onset
PRKCG modulates Fragile X-Associated Tremor/Ataxia Syndrome
PRKCG modulates Cgg-Associated Neurotoxicity