gene 887 words KG: ATM 2026-03-22
kind:genesection:genesstate:published
Contents

ATM Gene

🧬 Gene Info
Gene SymbolATM
Full NameAtaxia-Telangiectasia Mutated
Chromosome11q22.3
Protein TypeSerine/Threonine Kinase
Functionis a PIKK-family serine/threonine kinase that coordinates genomic stress responses, especially after DNA double-strand breaks.
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Dna Damage Response
UniProt ID[Q13315](https://www.uniprot.org/uniprotkb/Q13315)
Ensembl IDENSG00000149311
GeneCardsATM
Human Protein AtlasATM
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/CompoundsmtDNA, rapamycin
InteractionsSNCAIP, RB1CC1, MFN1, ERN1, PARKIN, FMR1
KG Connections1400 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
R-Loop Resolution Enhancement Therapy
Score: 0.43
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.38

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: contributes_to

Knowledge Graph (12 edges)

ATM interacts_with SNCAIP
ATM interacts_with RB1CC1
ATM interacts_with MFN1
ATM interacts_with ERN1
ATM interacts_with PARKIN
ATM interacts_with FMR1
ATM interacts_with SNCA
ATM interacts_with FAM134B
ATM interacts_with LC3
ATM interacts_with EPAS1