| Gene Symbol | ATR |
| Protein Type | Kinase |
| Function | encodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011]. |
| Pathways | mTOR, mtor, mTOR signaling, PI3K |
| GeneCards | ATR |
| Human Protein Atlas | ATR |
| CHK1 | Checkpoint enforcement, cell cycle arrest |
| RPA2 | Replication fork stabilization |
| p53 | Transcription regulation, apoptosis |
| FANCE | Fanconi anemia pathway |
| SMARCAL1 | Fork remodeling |
| Compound | Mechanism |
| VE-822 (VX-970) | ATR inhibitor |
| AZD6738 | ATR inhibitor |
| ETP-46464 | ATR inhibitor |
| Associated Diseases | Als, Ataxia, Cancer, Infection, Ms, Senescence |
| Known Drugs/Compounds | rapamycin |
| Interactions | RAD51, BAX, RAD54, VCP, FNDC5, EZH2 |
| KG Connections | 212 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |