gene 1,061 words KG: SCFD1 2026-03-21
kind:genesection:genesstate:published
Contents

SCFD1

🧬 Gene Info
Gene SymbolSCFD1
Chromosome9q34.3
Functionis a member of the Sec1/Munc18 (SM) protein family that plays essential roles in intracellular vesicle trafficking and membrane fusion events throughout the cell.
Primary Expressionboth excitatory glutamatergic and inhibitory GABAergic neurons - Present in astrocytes and oligodendrocytes - High expression
Molecular Weight41 kDa
Amino Acids372 aa
Exons14
Ensembl IDENSG00000084112
GeneCardsSCFD1
Human Protein AtlasSCFD1
gene = SCFD1name = Sec1 Family Domain Containing 1
ncbi_gene_id = 23256ensembl = ENSG00000084112
Associated DiseasesMs
InteractionsJAK2, KDM5D, EXERCISE, AGING, AMPK
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
KDM5D Gene
gene · KG edge: interacts_with
JAK2 Gene - Janus Kinase 2
gene · KG edge: interacts_with
FOXO1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SCFD1 interacts_with JAK2
SCFD1 associated_with AKT
SCFD1 interacts_with KDM5D
SCFD1 associated_with FOXO1
SCFD1 upregulates TREM2
SCFD1 modulates SNARE complex formation
SCFD1 associated_with APOPTOSIS
SCFD1 interacts_with EXERCISE
SCFD1 interacts_with Aging
SCFD1 associated_with Ms