| Gene Symbol | JAK2 |
| Aliases | Page for JAK2 Gene |
| Chromosome | 9p24.1 |
| Protein Type | Receptor |
| Function | is a critical non-receptor tyrosine kinase that mediates cytokine receptor signaling and plays essential roles in immune regulation, hematopoiesis, and cellular stress responses. |
| Primary Expression | neurons, astrocytes, microglia, and oligodendrocytes, where it participates in neuroinflammation, synaptic |
| Molecular Weight | 130 kDa |
| Amino Acids | 1132 aa |
| Pathways | JAK-STAT, JAK-STAT pathway |
| GeneCards | JAK2 |
| Human Protein Atlas | JAK2 |
| Drug | Specificity |
| Ruxolitinib | JAK1/JAK2 |
| Tofacitinib | JAK1/JAK2/JAK3 |
| Baricitinib | JAK1/JAK2 |
| Associated Diseases | ALS, Alzheimer, Autoimmune, Cancer, Carcinoma |
| Known Drugs/Compounds | ruxolitinib, curcumin, Curcumin, BARICITINIB, dasatinib, CURCUMIN |
| Interactions | STAT5, PDGFRB, CSF1R, AKT, STAT3, PNP |
| KG Connections | 1064 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |