gene 936 words KG: SEMA3F 2026-03-24
kind:genesection:genesstate:published
Contents

SEMA3F Gene

🧬 Gene Info
Gene SymbolSEMA3F
Full NameSemaphorin 3F
Chromosome3p21.31
Functionencodes a secreted axonal guidance molecule critical for neuronal development, synaptic organization, and vascular patterning.
Amino Acids810 aa
PathwaysAmyloid, Epigenetic
UniProt ID[Q13241](https://www.uniprot.org/uniprot/Q13241)
Ensembl IDENSG00000061656
GeneCardsSEMA3F
Human Protein AtlasSEMA3F
Associated Diseasesneurodegeneration
InteractionsAPOE4, AMYLOID, DENDRITE, APOE3, Actin,
KG Connections48 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
nrp1
gene · KG edge: binds

Knowledge Graph (12 edges)

SEMA3F inhibits PI3K-Akt-mTOR
SEMA3F upregulates Neutrophils
SEMA3F participates_in Tumor Suppression
SEMA3F downregulates AKT
SEMA3F downregulates STAT3
SEMA3F downregulates HIF-1alpha
SEMA3F downregulates VEGF
SEMA3F inhibits Tumor Angiogenesis
SEMA3F inhibits Tumor Metastasis
SEMA3F inhibits mTOR Signaling