gene 2,037 words KG: NRP1
Contents

NRP1 Gene

🧬 Gene Info
Gene SymbolNRP1
Full NameNeuropilin 1
Chromosome10p11.22
Protein TypeReceptor
Functionis a multi-domain transmembrane protein
Molecular Weight140 kDa
Exons27
PathwaysAngiogenesis, Cholesterol, NF-kB signaling, Nf-Kb, Tgf-Β
UniProt IDO14786
NCBI Gene ID4800
Ensembl IDENSG00000099250
OMIM602069
GeneCardsNRP1
Human Protein AtlasNRP1
CUB domains (a1, a2)Ligand binding for semaphorins
Associated DiseasesAls, Carcinoma, Diabetes, Hepatocellular Carcinoma, Type 2 Diabetes
InteractionsNGF, GAIN, APOE, SLC44A2, VEGF, HMGCR
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Retinal Vascular Microcirculation Rescue
Score: 0.54
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
MYC Gene
gene · KG edge: activates
HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase
gene · KG edge: activates

Knowledge Graph (12 edges)

NRP1 activates NGF
NRP1 inhibits GAIN
NRP1 activates APOE
NRP1 activates SLC44A2
NRP1 inhibits VEGF
NRP1 causes CD8
NRP1 causes CXCL10
NRP1 associated_with CD14
NRP1 activates HMGCR
NRP1 activates GLI1