gene

KMT2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KMT2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

38Outgoing

20Incoming

Summary

KMT2B — lysine methyltransferase 2B

View on Wiki →

🧬 Gene Info

Gene Symbol	KMT2B
Full Name	MLL2 (Mixed-Lineage Leukemia 2) / MLL4
Aliases	lysine methyltransferase 2B
Protein Family	SET1/MLL COMPASS Family
Protein Type	Transferase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	brain tissue
Subcellular Localization	Nucleus
Molecular Weight	445 kDa
Pathways	FMN-induced Anti-inflammatory Effect
UniProt ID	Q9UMN6
GeneCards	KMT2B
Human Protein Atlas	KMT2B
Alzheimer's Disease	Altered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's Disease	May affect dopaminergic neuron survival through transcriptional mechanisms
Associated Diseases	ALS, Alzheimer
Interactions	SHANK3, KMT2D, CACNA1G, KMT2A, SETD1A, NF-ΚB
KG Connections	58 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KMT2B — AlphaFold Q9UMN6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KMT2B["KMT2B"]
    RFK["RFK"]
    FMN_induced_Anti_inflammatory_["FMN-induced Anti-inflammatory Effect"]
    Alzheimer["Alzheimer"]
    Neuroinflammation["Neuroinflammation"]
    ALS["ALS"]
    Inflammation["Inflammation"]
    Als["Als"]
    Schizophrenia["Schizophrenia"]
    Autism["Autism"]
    TNFR1["TNFR1"]
    NF__B["NF-KappaB"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    AND["AND"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MICROGLIA["MICROGLIA"]
    Oxidative_Stress["Oxidative Stress"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    Nf__b["Nf-Kappab"]
    Microglia["Microglia"]
    KMT2B -->|"regulates"| RFK
    KMT2B -->|"regulates"| FMN_induced_Anti_inflammatory_
    KMT2B -->|"protects_agains"| Alzheimer
    KMT2B -->|"protects_agains"| Neuroinflammation
    KMT2B -->|"protects_agains"| ALS
    KMT2B -->|"protects_agains"| Inflammation
    KMT2B -->|"protects_agains"| Als
    KMT2B -.->|"inhibits"| Schizophrenia
    KMT2B -.->|"inhibits"| Autism
    KMT2B -.->|"inhibits"| TNFR1
    KMT2B -.->|"inhibits"| NF__B
    KMT2B -->|"protects_agains"| OXIDATIVE_STRESS
    KMT2B -.->|"inhibits"| AND
    KMT2B -->|"protects_agains"| ALZHEIMER_S_DISEASE
    KMT2B -.->|"inhibits"| RFK
    KMT2B -->|"protects_agains"| MICROGLIA
    KMT2B -->|"protects_agains"| Oxidative_Stress
    KMT2B -->|"protects_agains"| Synaptic_Plasticity
    KMT2B -.->|"inhibits"| Nf__b
    KMT2B -->|"protects_agains"| Microglia
    style KMT2B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (38)

Target	Relation	Type	Str
RFK	regulates	gene	0.90
FMN-induced Anti-inflammatory Effect	regulates	mechanism	0.85
Alzheimer	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Schizophrenia	inhibits	disease	0.65
Autism	inhibits	disease	0.65
TNFR1	inhibits	entity	0.60
SHANK3	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
KMT2A	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
SETD1A	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
RFK	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
Oxidative Stress	protects_against	pathway	0.60
Synaptic Plasticity	protects_against	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Microglia	protects_against	cell_type	0.60
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
INFLAMMATION	protects_against	gene	0.60
Ras	inhibits	protein	0.60
App	protects_against	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Microglia	expressed_in	cell_type	0.55
TNFR1	co_expressed_with	protein	0.50
NF-κB	inhibits	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50

Incoming (20)

Source	Relation	Type	Str
SETD1A	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
KMT2A	inhibits	gene	0.60
SHANK3	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
RFK	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
NF-ΚB	inhibits	gene	0.60
TNFR1	inhibits	protein	0.50
AUTISM	inhibits	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KMT2B

Understanding Entity Pages

Summary

Wiki Pages (8)

KMT2B — lysine methyltransferase 2B

setd1a

SHANK3 - SH3 and Multiple Ankyrin Repeat Domains 3

KMT2A — lysine methyltransferase 2A

MLL1 Histone H3K4 Methyltransferase (KMT2A)

MLL2/MLL4 Histone H3K4 Methyltransferase (KMT2B)