gene 1,532 words KG: TET3 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

TET3 Gene

🧬 Gene Info
Gene SymbolTET3
Full NameTet Methylcytosine Dioxygenase 3
Chromosome2p13.1
Protein FamilyTET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases)
Functioncatalyzing DNA demethylation
Primary Expressionneurons throughout the brain: - Cerebral cortex: Pyramidal neurons in layers 2-6 - Hippocampus: CA1, CA3, and dentate gyrus granule cells -
Amino Acids298 aa
UniProt IDQ8IU60
NCBI Gene ID200316
Ensembl IDENSG00000196950
OMIM617555
GeneCardsTET3
Human Protein AtlasTET3
Length2,298 amino acids
ApproachStatus
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsBMAL1, OCT4, TET1, TET2, STING, DNA
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.36
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (6)

Packard Center for ALS Research
institution · KG edge: regulates
CLOCK Gene
gene · KG edge: regulates
BMAL1 (ARNTL) Gene
gene · KG edge: inhibits
Genes
index · KG edge: regulates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

TET3 regulates GENES
TET3 regulates Als
TET3 regulates Ms
TET3 inhibits Epigenetic
TET3 expressed_in neurons
TET3 participates_in epigenetic regulation
CLOCK regulates TET3
BMAL1 inhibits TET3
OCT4 activates TET3
TET1 activates TET3