gene 1,427 words KG: TGFBI 2026-03-28
kind:genesection:genesstate:published
Contents

TGFBI

🧬 Gene Info
Gene SymbolTGFBI
Full NameTransforming Growth Factor Beta Induced Protein
Chromosome5q31.1
Functionis a secreted extracellular matrix (ECM) protein that plays crucial roles in cell adhesion, tissue development, and disease pathogenesis.
Molecular Weight75 kDa
Amino Acids683 aa
Exons17
PathwaysTGF-β
UniProt IDQ15582
NCBI Gene ID7045
Ensembl IDENSG00000120708
OMIM601692
GeneCardsTGFBI
Human Protein AtlasTGFBI
Encoded ProteinTGF-beta-induced protein
Associated DiseasesAls, Ms, Schizophrenia
InteractionsCANCER, GENES
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.45

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
PRDM1 Gene
gene · KG edge: protects_against
GJA1
gene · KG edge: associated_with
CD44 - Cell Surface Glycoprotein
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TGFBI protects_against PRDM1
TGFBI associated_with CD44
TGFBI associated_with GJA1
TGFBI regulates PRDM1
TGFBI associated_with Ms
TGFBI associated_with Schizophrenia
TGFBI associated_with Als
TGFBI regulates Cancer
TGFBI regulates Diabetes
TGFBI regulates Nf-Κb