gene 2,272 words KG: PRDM1 2026-03-25
kind:genesection:genesstate:published
Contents

PRDM1 Gene

🧬 Gene Info
Gene SymbolPRDM1
AliasesBlimp-1, PRDI-BF1, B lymphocyte-induced maturation protein 1
Chromosome6q21
Protein TypeTranscription Factor
Functionencodes a critical transcriptional repressor that controls plasma cell differentiation, immune cell function, and inflammatory responses.
Molecular Weight~105 kDa
Amino Acids982 aa
PathwaysCo-inhibitory Gene Module, Nf-Κb
UniProt IDO75663
NCBI Gene ID639
Ensembl IDENSG00000060656
OMIM603226
GeneCardsPRDM1
Human Protein AtlasPRDM1
Gene NamePRDI-BF1 and RZ-1 Homolog 1 (Blimp-1)
Associated DiseasesALS, DIABETES
InteractionsCD4, CD8, MAF, CANCER, RNA, PD-1
KG Connections92 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (11)

Packard Center for ALS Research
institution · KG edge: activates
GNA13 Gene
gene · KG edge: expressed_in
GJA1
gene · KG edge: protects_against
DISC1 — Disrupted in Schizophrenia 1
gene · KG edge: biomarker_for
DDX3X Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PRDM1 inhibits CD4
PRDM1 inhibits CD8
PRDM1 regulates Co-inhibitory Gene Module
PRDM1 interacts_with MAF
PRDM1 regulates TGFBI
PRDM1 regulates CD44
PRDM1 regulates GJA1
PRDM1 biomarker_for CD44
PRDM1 biomarker_for TGFBI
PRDM1 biomarker_for GJA1