gene 1,940 words KG: THBS4 2026-03-27
kind:genesection:genesstate:published
Contents

THBS4 Gene

🧬 Gene Info
Gene SymbolTHBS4
Full NameThrombospondin 4
Chromosome5q13.2
Functionis a secreted protein that
Primary Expressionthe nervous system and plays unique roles in neural circuit formation and maintenance [@born2017]
Molecular Weight110 kDa
Amino Acids870 aa
Exons22
PathwaysWnt
UniProt ID[P35443](https://www.uniprot.org/uniprot/P35443)
Ensembl IDENSG00000113205
GeneCardsTHBS4
Human Protein AtlasTHBS4
Chromosomal location5q13.2
Genomic size~16 kb
Associated Diseasesneurodegeneration
InteractionsTNF, TGFB1, EGFR, CYTOKINES, Egfr, P53
KG Connections18 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: activates
Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: encodes
Packard Center for ALS Research
institution · KG edge: activates
TGFB1 — Transforming Growth Factor Beta 1
gene · KG edge: activates
SMAD3 — SMAD Family Member 3
gene · KG edge: activates

Knowledge Graph (12 edges)

THBS4 activates TNF
THBS4 activates TGFB1
THBS4 activates EGFR
THBS4 activates CYTOKINES
THBS4 activates Diabetes
THBS4 activates Fibrosis
THBS4 activates Cardiomyopathy
THBS4 activates Als
THBS4 activates Wnt
THBS4 encodes Fibroblast