protein

Egfr

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Egfr: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2998Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	EGFR
Protein Family	ErbB/EGFR tyrosine kinase family
Protein Type	Receptor
Function	EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that binds EGF, TGF-α, and other ligands.
Primary Expression	neural stem cells, astrocytes, and neurons, where it regulates neurogenesis, gliogenesis, synaptic plasti
Molecular Weight	134.3 kDa
Pathways	Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt ID	[P00533](https://www.uniprot.org/uniprot/P00533)
GeneCards	EGFR
Human Protein Atlas	EGFR
Associated Diseases	Als, Alzheimer, Cancer, Epilepsy, Ferroptosis, Fibrosis
Interactions	MITOCHONDRIA, RIPK1, PPARG, WNT, TFEB, CFTR
KG Connections	338 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Egfr["Egfr"] -->|"regulates"| Ischemia["Ischemia"]
    style Ischemia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"interacts"| Fibrosis["Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"interacts"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"interacts"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"activates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"activates"| Hypertension["Hypertension"]
    style Hypertension fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Egfr["Egfr"] -->|"activates"| Obesity["Obesity"]
    style Obesity fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PPARG["PPARG"] -->|"regulates"| Egfr["Egfr"]
    style PPARG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PPARGC1A["PPARGC1A"] -->|"regulates"| Egfr["Egfr"]
    style PPARGC1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| Egfr["Egfr"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SREBF1["SREBF1"] -->|"regulates"| Egfr["Egfr"]
    style SREBF1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LAMP1["LAMP1"] -->|"regulates"| Egfr["Egfr"]
    style LAMP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Egfr fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1887)

Target	Relation	Type	Str
Ischemia	regulates	disease	0.60
Fibrosis	interacts_with	disease	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Cancer	activates	disease	0.60
Als	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Als	inhibits	disease	0.60
Als	activates	disease	0.60
Diabetes	activates	disease	0.60
Hypertension	activates	disease	0.60
Obesity	activates	disease	0.60
Fibrosis	associated_with	disease	0.60
Leukemia	activates	disease	0.60
Pyroptosis	activates	disease	0.60
Cancer	associated_with	disease	0.60
Als	therapeutic_target	disease	0.60
Glioblastoma	therapeutic_target	disease	0.60
Cancer	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Ferroptosis	inhibits	disease	0.60
Fibrosis	causes	disease	0.60
Als	causes	disease	0.60
Epilepsy	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Als	regulates	disease	0.60
Cancer	regulates	disease	0.60
Glioblastoma	associated_with	disease	0.60
Glioblastoma	activates	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Als	contributes_to	disease	0.60
Cancer	inhibits	disease	0.60
Aging	regulates	disease	0.60
Dementia	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Neurodegeneration	activates	disease	0.60
Alzheimer	activates	disease	0.60
Ferroptosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Cardiomyopathy	activates	disease	0.60
Alzheimer	interacts_with	disease	0.60
Aging	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Neuroinflammation	associated_with	disease	0.60

Incoming (1111)

Source	Relation	Type	Str
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
SREBF1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
RAS	regulates	gene	0.60
CPT1A	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
MTOR	regulates	gene	0.60
RIPK1	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
BACE1	therapeutic_target	gene	0.60
TCR	therapeutic_target	gene	0.60
FUT8	regulates	gene	0.60
ST6GAL1	regulates	gene	0.60
APP	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
ERBB3	therapeutic_target	gene	0.60
STING	inhibits	gene	0.60
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
CD8	activates	gene	0.60
PD-1	inhibits	gene	0.60
CCND1	expressed_in	gene	0.60
BCL2L1	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
IL1B	expressed_in	gene	0.60
ELF3	expressed_in	gene	0.60
EGFR	interacts_with	gene	0.60
CYTOKINES	expressed_in	gene	0.60
RNA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Egfr

Understanding Entity Pages

Wiki Pages (20)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

lithium-tauopathy

Growth Factor Therapeutics: Investment Landscape Analysis

creatine-supplementation-neurodegeneration

Genistein for Mild Cognitive Impairment (NCT07385937)

Neurogenesis

Creatine for Neuroprotection

substance-p-nk1-signaling-neurodegeneration

RICTOR Protein

LIN7B — Lin-7 Homolog B

Heat Shock Protein Response Pathway in Neurodegeneration

Flotillin-1 Protein

Adult Neurogenesis in Neurodegenerative Disease

TEAD1 — TEA Domain Transcription Factor 1

EGFR Signaling in Parkinson's Disease