gene 1,377 words KG: TMEM59 2026-03-26
kind:genesection:genesstate:published
Contents

TMEM59 Gene

🧬 Gene Info
Gene SymbolTMEM59
Full NameTransmembrane Protein 59
Chromosome9q34.3
Protein TypeType I transmembrane protein
Functionencodes a type I transmembrane protein with a lumenal N-terminus, a single transmembrane domain, and a short cytoplasmic C-terminal tail.
Subcellular LocalizationGolgi apparatus, Endoplasmic Reticulum
Pathwayspathway: #### Golgi Function
UniProt IDQ9H0M0
NCBI Gene ID9528
Ensembl IDENSG00000115616
OMIM610024
GeneCardsTMEM59
Human Protein AtlasTMEM59
Associated DiseasesALS, Alzheimer, Parkinson
InteractionsPRDX3, SSBP1, CALB1, RNF14, CCT4, ULK2
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Microbial Inflammasome Priming Prevention
Score: 0.58
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

IGF2R Protein
protein · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM59 associated_with SFPQ
TMEM59 associated_with CCT4
TMEM59 associated_with CALB1
TMEM59 associated_with SORL1
TMEM59 associated_with IGF2R
TMEM59 associated_with STXBP3
TMEM59 associated_with RNF14
TMEM59 associated_with APOE
TMEM59 associated_with PRDX3
TMEM59 associated_with ULK2