gene 1,828 words KG: TMX2
Contents

TMX2 Gene

🧬 Gene Info
Gene SymbolTMX2
Full Nametmx2
Protein TypeGene
FunctionThe protein's topology places its redox-active domain in the ER lumen, where it can interact with other ER-resident proteins involved in disulfide bond formation and protein folding.
Subcellular Localizationthe endoplasmic reticulum (ER) membrane, where it participates in ER redox homeostasis and protein quality control mecha
Molecular Weight32 kDa
PathwaysAutophagy, Oxidative Stress, Mitophagy, CRISPR-Cas, autophagy pathway
NCBI Gene IDSearch NCBI
GeneCardsTMX2
Human Protein AtlasTMX2
Associated DiseasesHepatocellular Carcinoma, Poor Prognosis
InteractionsVDAC2, TFEB, PRKN, GAIN, AUTOPHAGY, OXIDATIVE STRESS
KG Connections50 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (3)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (7)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
PRKN — Parkin RBR E3 Ubiquitin Protein Ligase
gene · KG edge: interacts_with
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: activates
Genes
index · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

TMX2 interacts_with VDAC2
TMX2 activates TFEB
TMX2 interacts_with PRKN
TMX2 activates GAIN
TMX2 promotes macroautophagy
TMX2 modulates KPNB1
TMX2 modulates TFEB
TMX2 promotes_nuclear_import_of TFEB
TMX2 facilitates_nuclear_export_of KPNB1
TMX2 promotes hepatocellular carcinoma