gene 1,051 words KG: TRPC6
Contents

TRPC6 Gene

🧬 Gene Info
Gene SymbolTRPC6
Chromosome11q22.1
Protein TypeGene
Functionencodes a non-selective calcium-permeable cation channel belonging to the TRPC (Transient Receptor Potential Canonical) family.
Primary Expressionnumerous tissues, including the brain, kidney, heart, and lung, where it participates in diverse physiological processes ranging from neuronal signali
Subcellular Localizationthe plasma membrane of soma and dendrites, where it contributes to synaptic plasticity, dendritic spine morphology, and
Amino Acids931 aa
Exons13
PathwaysPI3K
GeneCardsTRPC6
Human Protein AtlasTRPC6
Associated DiseasesAls, calcium influx, Cardiovascular, Diabetes, Hypertension
InteractionsAKT, AND, APOPTOSIS, App, Bdnf, BDNF
KG Connections64 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Orexin-Microglia Modulation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Mitochondria
entity · KG edge: activates
Genes
index · KG edge: associated_with
BDNF Gene
gene · KG edge: activates
HCRTR1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TRPC6 therapeutic_target HCRTR1
NFATC1 activates TRPC6
TRPC6 causes calcium influx
PIEZO1 activates TRPC6
HCRTR1 associated_with TRPC6
TRPC6 associated_with PNOC
TRPC6 associated_with HCRTR2
PNOC associated_with TRPC6
HCRTR2 associated_with TRPC6
TRPC6 therapeutic_target PNOC

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