gene 1,467 words KG: VPS29
Contents

VPS29 Gene

🧬 Gene Info
Gene SymbolVPS29
Chromosome12q24.33
Functionis a critical component of the retromer complex, a highly conserved protein assembly that plays a fundamental role in endosomal trafficking throughout the cell.
Molecular Weight21 kDa
Amino Acids182 aa
Exons5
PathwaysCRISPR-Cas, Stem Cell
UniProt IDQ9BRT6
NCBI Gene ID51699
Ensembl IDENSG00000136840
GeneCardsVPS29
Human Protein AtlasVPS29
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, App, GENES, GENETIC MODIFIERS
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Lysosomal Enzyme Trafficking Correction
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Oligodendrocyte White Matter Vulnerability
Score: 0.65

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Progressive Supranuclear Palsy (PSP)
disease · KG edge: activates
Genes
index · KG edge: activates
MAPT - Microtubule-Associated Protein Tau
gene · KG edge: activates
vps26
gene · KG edge: binds_to
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

TAU activates VPS29
PSP activates VPS29
VPS29 activates MAPT
MAPT activates VPS29
VPS29 modulates Tau Propagation
VPS29 activates TAU
VPS26 binds_to VPS29
VPS29 binds_to VPS35
VPS29 component_of RETROMER COMPLEX
VPS26 interacts_with VPS29

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.