gene 1,704 words KG: VPS26
Contents

VPS26 Gene

🧬 Gene Info
Gene SymbolVPS26
Chromosome10q21.3
Functionencodes a critical component of the retromer complex, a key regulator of endosomal protein trafficking that has emerged as a central player in neurodegenerative disease pathogenesis.
Molecular Weight36.5 kDa
Amino Acids326 aa
PathwaysAutophagy
Ensembl IDENSG00000171208
GeneCardsVPS26
Human Protein AtlasVPS26
Associated DiseasesAls, Ms
InteractionsVPS29, VPS35, ABCA1, ABCA7, CD2AP, PICALM
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Lysosomal Enzyme Trafficking Correction
Score: 0.49
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: associated_with
VPS35 — Vacuolar Protein Sorting 35 Homolog
gene · KG edge: binds_to
VPS29 Gene
gene · KG edge: binds_to
SNAP29 — Synaptosomal-Associated Protein 29
gene · KG edge: associated_with

Knowledge Graph (12 edges)

VPS26 associated_with AKT1
VPS26 associated_with EGFR
VPS26 associated_with SNAP29
VPS26 binds_to VPS29
VPS26 binds_to VPS35
VPS26 interacts_with VPS29
VPS26 interacts_with VPS35
VPS26 activates VPS35
VPS26 associated_with MICRORNAS
VPS26 regulates AUTOPHAGY