| Gene Symbol | SMCR8 |
| Full Name | SMCR8, SMOX Modifier 1 |
| Aliases | C9orf72 modifier, FTDALS2 |
| Chromosome | 9p21.1 |
| Function | SMCR8 (SMCR8 - SMOX Modifier 1) is a protein coding gene that functions as a positive regulator of autophagy and lysosomal trafficking. |
| Primary Expression | neurons and glial cells, where it participates in cellular clearance mechanisms critical for neuronal health |
| Molecular Weight | ~53 kDa |
| Amino Acids | 479 aa |
| Exons | 12 |
| Pathways | Autophagy, Mtor, Oxidative Stress |
| UniProt ID | Q8TBX5 |
| NCBI Gene ID | 94015 |
| GeneCards | SMCR8 |
| Human Protein Atlas | SMCR8 |
| Gene Length | 35.2 kb |
| Associated Diseases | AD, ALI, AMI, Als, Ftd, ILD |
| Known Drugs/Compounds | rapamycin |
| Interactions | CALCOCO2, LC3, BECN1, C9ORF72, NBR1, G3BP1 |
| KG Connections | 240 knowledge graph edges |
| Databases | GeneCardsHPASTRING |