gene 707 words KG: FLCN 2026-03-24
kind:genesection:genesstate:published
Contents

FLCN Gene

🧬 Gene Info
Gene SymbolFLCN
Full NameFolliculin
AliasesBHD, FLCN1, MGC19765
Chromosome17p11.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons and glia - Highest expression in: - Cerebral cortex - [Hippocampus](/brain-regions/hippocamp
PathwaysmTOR, mtor, AMPK, mTOR Signaling
UniProt IDQ8IVG7
GeneCardsFLCN
Human Protein AtlasFLCN
Entrez Gene ID201163
FNIP1FLCN-interacting protein, regulates metabolism
FNIP2FLCN-interacting protein 2
mTORPart of mTORC1/2 complexes
AMPKEnergy sensing kinase
Associated DiseasesALS, Kidney Cancer
Known Drugs/Compoundsrapamycin
InteractionsTFEB, CGAS, NOTCH1, NF1, C9ORF72, STING
KG Connections129 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
fip200
gene · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

FLCN activates TFEB
FLCN regulates TFEB
FLCN activates CGAS
FLCN interacts_with TFEB
FLCN activates NOTCH1
FLCN activates NF1
FLCN interacts_with C9ORF72
FLCN activates STING
FLCN interacts_with GABARAP
FLCN activates MITF