gene 967 words KG: WWOX
Contents

WWOX Gene

🧬 Gene Info
Gene SymbolWWOX
Full NameWW Domain Containing Oxidoreductase
Chromosome16q23.1
Functionencodes a tumor suppressor protein with two WW domains and a short-chain dehydrogenase/reductase (SDR) domain.
Primary Expressionthe brain, particularly in the cerebellum, cortex, and hippocampus
Amino Acids414 aa
PathwaysApoptosis, Tgf-Β
UniProt IDQ9H0M0
NCBI Gene ID54345
OMIM605515
GeneCardsWWOX
Human Protein AtlasWWOX
Associated DiseasesAlzheimer, Carcinoma
InteractionsMMP2, TAU, SMAD3, SMAD4, P38, APP
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (5)

AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (8)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: interacts_with
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

WWOX expressed_in VIM
WWOX activates MMP2
WWOX activates TAU
WWOX activates SMAD3
WWOX activates SMAD4
WWOX activates P38
WWOX activates APP
WWOX inhibits TAU
WWOX interacts_with JNK
WWOX regulates CANCER