gene 866 words KG: SMAD4 2026-03-21
kind:genesection:genesstate:published
Contents

SMAD4 — SMAD Family Member 4

🧬 Gene Info
Gene SymbolSMAD4
Full NameSMAD Family Member 4
Chromosome18q21.1
Functionis a central mediator of TGF-beta signaling in the nervous system.
Molecular Weight60 kDa
Amino Acids552 aa
PathwaysTGF-β
UniProt IDQ99707
NCBI Gene ID4089
Ensembl IDENSG00000141646
OMIM600993
GeneCardsSMAD4
Human Protein AtlasSMAD4
Official SymbolSMAD4
Official Full NameSMAD Family Member 4
Associated DiseasesCancer
InteractionsLC3, P38, CTSD, TGFB1, BNIP3L, OVERVIEW
KG Connections198 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Caspase-3 (CASP3)
protein · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits

Knowledge Graph (12 edges)

SMAD4 regulates SMAD2
SMAD4 activates LC3
SMAD4 activates P38
SMAD4 regulates SMAD3
SMAD4 activates CTSD
SMAD4 treats OVERVIEW
SMAD4 activates TGFB1
SMAD4 activates BNIP3L
SMAD4 associated_with APC
SMAD4 associated_with PIK3CA