PDIA3

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDIA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for PDIA3 - Protein Disulfide Isomerase Family A Member 3

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graph TD
    PDIA3["<b>PDIA3</b>"]
    TGF__["TGF-beta"]
    PDIA3 -->|"interacts with"| TGF__
    fibroblast_activation(["fibroblast activation"])
    PDIA3 -->|"activates"| fibroblast_activation
    Als{"Als"}
    PDIA3 -->|"expressed in"| Als
    Senescence{"Senescence"}
    PDIA3 -->|"activates"| Senescence
    Aging{"Aging"}
    PDIA3 -->|"regulates"| Aging
    PDIA3 -->|"activates"| Als
    Ms{"Ms"}
    PDIA3 -->|"regulates"| Ms
    Tumor{"Tumor"}
    PDIA3 -->|"activates"| Tumor
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    PDIA3 -->|"activates"| Unfolded_Protein_Response
    Autophagy(["Autophagy"])
    PDIA3 -->|"expressed in"| Autophagy
    BMAL1["BMAL1"]
    PDIA3 -->|"regulates"| BMAL1
    AHR["AHR"]
    PDIA3 -->|"regulates"| AHR
    ERP57["ERP57"]
    ERP57 -->|"activates"| PDIA3
    AGING["AGING"]
    AGING -->|"regulates"| PDIA3
    MTOR["MTOR"]
    MTOR -->|"regulates"| PDIA3
    MYC["MYC"]
    MYC -->|"activates"| PDIA3
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| PDIA3
    XPA["XPA"]
    XPA -->|"activates"| PDIA3
    CLOCK["CLOCK"]
    CLOCK -->|"activates"| PDIA3
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| PDIA3
    style PDIA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0