gene 946 words KG: XRCC3 2026-03-24
kind:genesection:genesstate:published
Contents

XRCC3

🧬 Gene Info
Gene SymbolXRCC3
Full NameX-Ray Repair Cross Complementing 3
Chromosome14q32.33
FunctionXRCC3 functions primarily in the homologous recombination pathway of DNA double-strand break (DSB) repair:
Subcellular Localization## Protein Structure
Molecular Weight38 kDa
PathwaysApoptosis, Invasion
UniProt ID[Q9UQE5](https://www.uniprot.org/uniprot/Q9UQE5)
Ensembl IDENSG00000113147
OMIM600675
GeneCardsXRCC3
Human Protein AtlasXRCC3
Associated DiseasesTumor
InteractionsBAX, DNA, P53, APOPTOSIS, CANCER
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (1)

SASP-Mediated Complement Cascade Amplification
Score: 0.70

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
BAX Gene
gene · KG edge: activates
Genes
index · KG edge: expressed_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates

Knowledge Graph (12 edges)

XRCC3 activates BAX
XRCC3 expressed_in GENES
XRCC3 activates DNA
XRCC3 activates P53
XRCC3 activates Cancer
XRCC3 activates Als
XRCC3 associated_with Tumor
XRCC3 activates Apoptosis
XRCC3 activates Prostate Cancer
XRCC3 activates Invasion