| Gene Symbol | HSPA1B |
| Full Name | Heat Shock Protein 70 Family Member 1B |
| Chromosome | 6p21.33 |
| Protein Type | Chaperone |
| Function | HSPA1B is located in the major histocompatibility complex class III region on chromosome 6p21.33, adjacent to HSPA1A |
| Primary Expression | Cerebral cortex, Hippocampus, Widespread |
| Molecular Weight | 70 kDa |
| UniProt ID | P0DMV8 |
| NCBI Gene ID | 3305 |
| OMIM | 603338 |
| GeneCards | HSPA1B |
| Human Protein Atlas | HSPA1B |
| N-terminal ATPase domain (~45 kDa) | Binds and hydrolyzes ATP, regulating substrate binding |
| Substrate-binding domain (~25 kDa) | Binds hydrophobic peptide segments of misfolded proteins |
| C-terminal EEVD motif | Coordinates co-chaperones (Hsp40, Hsp70/Hsp90-organizing protein) |
| Associated Diseases | AD, ALI, Als, Autoimmune, Cardiovascular |
| Interactions | ager, AGER, ALS, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, C9ORF72 |
| KG Connections | 137 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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