protein 3,134 words KG: HUNTINGTIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Huntingtin (HTT)

🔬 Protein Info
Gene SymbolHUNTINGTIN
Full NameHuntingtin (HTT)
Protein TypeProtein
Functionis a large protein encoded by the HTT gene, most famous for its role in Huntington's disease where CAG repeat expansion in the first exon leads to mutant huntingtin (mHTT).
Molecular Weight350 kDa
Amino Acids144 aa
PathwaysNF-ÎșB
UniProt IDSearch UniProt
GeneCardsHUNTINGTIN
Human Protein AtlasHUNTINGTIN
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/CompoundsRAPAMYCIN
InteractionsCGAS, STING, MTOR, LC3, HTT, BDNF
KG Connections691 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

HUNTINGTIN inhibits CA2_HOMEOSTASIS
HUNTINGTIN associated_with BECN1
HUNTINGTIN associated_with GABARAP
HUNTINGTIN associated_with TFEB
HUNTINGTIN associated_with ALS4
HUNTINGTIN associated_with TAU
HUNTINGTIN activates CGAS
HUNTINGTIN activates STING
HUNTINGTIN regulates PRESENILIN-1
HUNTINGTIN expressed_in C1Q