protein 2,221 words KG: BECN1 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

BECN1 Protein (Beclin-1)

🔬 Protein Info
Gene SymbolBECN1
Protein FamilyPI3K complex, autophagy family
FunctionBECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationCytoplasm, Golgi apparatus, endoplasmic reticulum, mitochondria
Molecular Weight~60 kDa
PathwaysAkt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt IDQ14457
Ensembl IDENSG00000126581
GeneCardsBECN1
Human Protein AtlasBECN1
Protein NameBeclin-1
GeneBECN1
PDB ID5GUI, 5HJI, 4L67
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
Known Drugs/CompoundsRAPAMYCIN, SORAFENIB, rapamycin, nicotine, crocin, HCQ
InteractionsC9ORF72, NBR1, G3BP1, TOLLIP, SQSTM1, NDP52
KG Connections2944 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58

Related Analyses (19)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AIF1 Gene
gene · KG edge: activates
ADNP Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BECN1 associated_with PINK1
BECN1 associated_with STAT3
BECN1 co_discussed CGAS
BECN1 co_discussed JNK
BECN1 co_discussed P62
BECN1 co_discussed CLDN5
BECN1 co_discussed HIF1A
BECN1 co_discussed LC3
BECN1 upregulates LC3
BECN1 regulates TAU