mechanism 1,685 words KG: ferroptosis 2026-03-31
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Ferroptosis in Parkinson's Disease

Mechanism Info
Nameferroptosis
SummaryAn iron-dependent, lipid peroxidation-driven form of programmed cell death that contributes to dopaminergic neuron loss in Parkinson's disease.
Key Genes/ProteinsSLC7A11, GPX4, sorcin, NRF2, STING, PCK2
Related Diseaseslipid_peroxidation, Ischemia/Reperfusion Injury, iron overload
Linked Hypotheses10 hypotheses

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Extracellular Matrix Stiffness Modulation
Score: 0.43
Ferroptosis Inhibition for α-Synuclein Neuroprotection
Score: 0.55

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40

See Also (4)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: regulates
ABCA7 (Redirect)
redirect · KG edge: protects_against
acc-chronic-pain
cell_type · KG edge: activates

Knowledge Graph (12 edges)

ferroptosis contributes_to osteoarthritis
ferroptosis causes HSC
ferroptosis contributes_to diabetic_nephropathy
ferroptosis regulates lipid_peroxidation
ferroptosis regulates iron metabolism
ferroptosis regulates cysteine metabolism
ferroptosis causes neurodegeneration
ferroptosis causes myocardial ischemia-reperfusion injury
ferroptosis causes tumor cells
ferroptosis causes hemorrhagic transformation