Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACUTE KIDNEY INJURY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ACUTE KIDNEY INJURY |
Knowledge base pages for this entity
graph TD
ACUTE_KIDNEY_INJURY["ACUTE KIDNEY INJURY"]
Ischemia_Reperfusion_Injury["Ischemia-Reperfusion Injury"] -->|"causes"| ACUTE_KIDNEY_INJURY
cisplatin["cisplatin"] -->|"causes"| ACUTE_KIDNEY_INJURY
STAT3["STAT3"] -->|"target for"| ACUTE_KIDNEY_INJURY
STAT3_inhibition["STAT3 inhibition"] -.prevents.-> ACUTE_KIDNEY_INJURY
Sepsis["Sepsis"] -->|"causes"| ACUTE_KIDNEY_INJURY
AMPK["AMPK"] -.protects against.-> ACUTE_KIDNEY_INJURY
Methamphetamine["Methamphetamine"] -->|"causes"| ACUTE_KIDNEY_INJURY
Ferroptosis["Ferroptosis"] -->|"contributes to"| ACUTE_KIDNEY_INJURY| Target | Relation | Type | Str |
|---|---|---|---|
| EGR1 | associated_with | gene | 0.85 |
| Renal Ischemia-Reperfusion Injury | associated_with | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Ischemia-Reperfusion Injury | causes | process | 0.95 |
| cisplatin | causes | drug | 0.95 |
| Ferroptosis | associated_with | process | 0.95 |
| STAT3 | therapeutic_target | protein | 0.94 |
| STAT3 inhibition | prevents | process | 0.93 |
| TFAM | protects_against | protein | 0.92 |
| Sepsis | causes | disease | 0.92 |
| AMPK | protects_against | protein | 0.92 |
| Methamphetamine | causes | drug | 0.90 |
| Redox Imbalance | contributes_to | mechanism | 0.90 |
| Reactive Oxygen Species | associated_with | process | 0.90 |
| Ferroptosis | contributes_to | process | 0.90 |
| Mitophagy | protects_against | process | 0.88 |
| Redox Imbalance | associated_with | process | 0.85 |
| HK2 | associated_with | gene | 0.85 |
| ketamine | treats | drug | 0.85 |
| Ferroptosis | causes | process | 0.85 |
| Glycolysis | associated_with | pathway | 0.85 |
| Ceria Nanoparticles | treats | chemical | 0.80 |
| Atorvastatin | treats | drug | 0.80 |
| ferroptosis | associated_with | process | 0.80 |
| HK2 | contributes_to | gene | 0.80 |
| Renal Tubular Epithelial Cells | involved_in | cell_type | 0.80 |
| renal tubular epithelial cells | implicated_in | cell_type | 0.80 |
| mitochondrial dysfunction | contributes_to | phenotype | 0.80 |
| Lipopolysaccharide | causes | compound | 0.75 |
| Glycolysis | contributes_to | pathway | 0.75 |
| semaglutide | causes | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||