mechanism 1,706 words KG: PLA2G6 2026-04-01
section:mechanismskind:mechanismevidence:strongtopic:mitochondrialtopic:pediatric-neurodegenerationstate:published
Contents

Infantile Neuroaxonal Dystrophy (INAD) Pathway

Mechanism Info
NameInfantile Neuroaxonal Dystrophy (INAD) Pathway
SummaryComprehensive mechanistic overview of infantile neuroaxonal dystrophy (INAD/PLA2G6-associated neurodegeneration), covering PLA2G6 mutations, axonal transport dysfunction, iron accumulation, and developmental regression
Key Genes/ProteinsVPS13C, GENES
Related DiseasesPhospholipase A2 Group VI-Associated Neurodegeneration, neurodegeneration, Schizophrenia, Neurodegeneration, Parkinson's disease
Related Pathwaysdemyelination

Knowledge Graph

Related Hypotheses (19)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Transcriptional Autophagy-Lysosome Coupling
Score: 0.68
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.51
Noradrenergic-Tau Propagation Blockade
Score: 0.51

Related Analyses (30)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

PLA2G6 upregulates SCHIZOPHRENIA
PLA2G6 associated_with neurodegeneration
PLA2G6 interacts_with PLA2G4A
PLA2G6 co_discussed MMP2
PLA2G6 co_discussed C3
PLA2G6 co_discussed PLA2G4A
PLA2G6 co_discussed IL1B
PLA2G6 co_discussed DNASE2
PLA2G6 co_discussed STING1
PLA2G6 activates PLA2G4A