protein 606 words KG: PLA2G6 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PLA2G6 Protein (iPLA2-VI)

🔬 Protein Info
Gene SymbolPLA2G6
Full NamePLA2G6 (iPLA2-VI)
AliasesiPLA2-VI
Chromosome22q13.1
Protein TypeEnzyme
Target ClassEnzyme
FunctionPhospholipid remodeling - generates lysophospholipids and free fatty acids
Mechanism of ActionSmall molecule inhibitor of calcium-independent phospholipase A2 activity
DruggabilityLow (0.36)
Clinical StageApproved
Molecular Weight90 kDa
Amino Acids752 aa
PathwaysCellular senescence / SASP signaling, Ros
UniProt IDQ9NP81
GeneCardsPLA2G6
Human Protein AtlasPLA2G6
Associated DiseasesALS, ALZHEIMER, Dystonia, Ms
Known Drugs/CompoundsBEL
InteractionsPLA2G4A, TAU, HDAC3, MECP2, Rb, WDR45
SciDEX TargetView Target Profile (8 clinical trials)
KG Connections215 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Aquaporin-4 Polarization Rescue
Score: 0.51

Related Analyses (11)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: associated_with
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: co_discussed
FTL Gene
gene · KG edge: associated_with
FBXO7 — F-Box Protein 7
gene · KG edge: associated_with
FA2H Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PLA2G6 associated_with neurodegeneration
PLA2G6 interacts_with PLA2G4A
PLA2G6 co_discussed MMP2
PLA2G6 co_discussed C3
PLA2G6 co_discussed PLA2G4A
PLA2G6 co_discussed IL1B
PLA2G6 co_discussed DNASE2
PLA2G6 co_discussed STING1
PLA2G6 activates PLA2G4A
PLA2G6 inhibits PLA2G4A